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    Rivaroxaban (Xarelto▼): reminder that 15 mg and 20 mg tablets should be taken with food

    Advice for healthcare professionals:

    • remind patients to take rivaroxaban 15 mg or 20 mg tablets with food
    • for patients who have difficulty swallowing, tablets can be crushed and mixed with water or apple puree immediately before taking; this mixture should be immediately followed by food
    • rivaroxaban 2.5 mg and 10 mg tablets can be taken with or without food
    • report suspected adverse drug reactions, including any suspected events associated with lack of efficacy to rivaroxaban, on a Yellow Card

    Importance of taking rivaroxaban 15 mg and 20 mg tablets with food

    Clinical trials of rivaroxaban showed that food intake does not affect absorption of 2.5 mg or 10 mg tablets, while absorption of 20 mg tablets was optimal when taken with high-fat, high-calorie meal.

    For this reason, rivaroxaban 15 mg and 20 mg tablets are to be taken with food.

    MHRA has received a small number of reports of patients taking rivaroxaban 15 mg or 20 mg who experienced a thromboembolic event, which the reporter

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